Susceptibility to ocular autoimmune disease

Genetic susceptibility to autoimmune liver disease.

Autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are considered as putative autoimmune diseases of the liver. Whereas strong evidence that bacterial infection may trigger PBC exists, the etiologies for PSC and AIH remain unknown. Although there have been significant discoveries of genetic polymorphisms that may underlie the susceptibility to t...

Autoimmune Inner Ear Disease- A Clinical Viewpoint

Recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. In particular, advances have occurred in our understanding of the Autoimmune Inner Ear Disease (AIED). In this article, the authors review the different postulated theories in the pathogenesis of this disease. The clinical presentation, the available para-clinical diagnostic to...

Ocular disease due to brucellosis.

ALL the chronic granulomatous infections may occasionally give rise to ocular disease, and tuberculosis and syphilis are the best known in Great Britain. Brucellosis is an infection which should, at least in its chronic forms, be regarded as an important member of this group, and ought to be remembered as a possibility when the cause of certain eye diseases is being investigated. Standard text-...

Ocular Disease Due to Brucellosis.

No Association of PTPN22 Polymorphisms with Susceptibility to Ocular Behcet's Disease in Two Chinese Han Populations

BACKGROUND Behcet's disease is known as a recurrent, multisystem inflammation and immune-related disease. Protein tyrosine phosphatase non-receptor 22 (PTPN22) is a key negative regulator of T lymphocytes and polymorphisms of the PTPN22 gene have been shown to be associated with various immune-related diseases. The present study was performed to assess the association between PTPN22 polymorphis...